The governor of a Mexican state is assassinated. Soon after, junior executive Daryl Chase's life turns upside down: after he flags a huge transfer of funds from a Mexican account as probably illegal, he's attacked in his apartment, rescued by a CIA agent, finds his secretary shot dead, and witnesses two cops get killed. He calls the CIA guy who tells him to grab the next train to Mexico. Leaving Manhattan, Daryl can't shake a jive-talking street punk named Freddy, and soon he's traded clothes with Freddy to escape the police. Within days, his girlfriend, his boss, his client, Freddy, the FBI, and the dead governor's dog are tangled in a web of deceit and danger. Who's who?

In New York, Detective Alberto Santana comes with his partner Joseph Bruno to meet his wife Gina and his daughter Celeste to celebrate her eighteenth birthday. Out of the blue, Alberto is shot in his head on the sidewalk by a man wearing a hood that delivers a religious message from the Lord. Many years later, Celeste is a detective of the New York Police Department and partner of Joe Bruno. When the crooks Alden and Jeff Kane, who had torched their buildings to receive the insurance, are released from prison, they are executed by two criminals in the same modus operandi of detective Santana, and the police department concludes that they are the same killers. Lieutenant Diaz assigns Detective Manso and Detective Demarco from narcotics to investigate the case, for the deception of Celeste. Then the drug dealer Chino and his gang are executed in Manhattan's Lower East Side by the killers Dante and his deformed and deranged twin brother Perfecto...